http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SE-8301039-D0
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27a71ddaaa2f5a8c228fc6cb3f3b3098 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-096 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-445 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4433 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-443 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-096 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-64 |
| filingDate | 1983-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f52c45ce7aa6a4e4fe97cbddedea86c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_072efd29fb0a02febd3141ee0ae2a792 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f6e0bade9b32dd38cbab9c3281e7778 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d95d9b49140189e621b1f89b05c2e92a |
| publicationDate | 1983-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SE-8301039-D0 |
| titleOfInvention | HETEROCYCLIC DERIVATIVES |
| abstract | Compounds of the formula (I):- <IMAGE> and physiologically acceptable salts, hydrates and bioprecursors thereof have been found to show pharmacological activity as selective histamine H2-antagonists. In formula (I> R1 represents hydrogen, C1-14 alkyl, cycloalkyl, alkenyl, aralkyl, heteroaralkyl, trifluoroalkyl or substituted alkyl; and R2 represents hydrogen or C1-4 alkyl; or R1 and R2 together complete an optionally substituted 5 to 10 membered ring; Alk represents C1-3 alkylene; Q represents a furan or thiophene bonded via the 2- and 5- positions, the furan or thiophene ring optionally bearing a further substituent R4 adjacent to the group R1R2N-Alk-; or Q represents a thiophene ring bonded via the 2- and 4- positions, the thiophene ring optionally bearing a further substituent R4 adjacent to the group R1R2NAlk with the proviso that when the group R1R2 NAlk is in the 4- position then the group R4 is in the 5-position; or Q represents a benzene ring bonded via the 1- and 3- or 1- and 4-positions; R4 represents halogen or C1-4 alkyl which may be substituted by hydroxy or C1-4 alkoxy; X represents oxygen, sulphur-, -NH-, methylene or a bond; Y represents oxygen, sulphur, methylene or a bond; n represents zero, 1, 2 or 3 and m is an integer from 2 to 5, with the provisos that (a) the total number of atoms in the chain X(CH2)nY(CH2)m is an integer from 3 to 8, (b) when X and Y represents oxygen or sulphur then n is 2 or 3, (c) when X represents -NH- then Q is a benzene ring and Y represents methylene or a bond, and (d) when Q represents a benzene ring, X represents oxygen, and n represents 1, then m may additionally represent 1 and Y may additionally represent -CHOR14 where R14 represents hydrogen or acyl; and R3 represents hydrogen, alkyl, alkenyl, aralkyl, or C2-6 alkyl substituted by hydroxy or alkoxy; either A represents N and B min represents CR5; or A represents CR5 and B represents N; and R5 represents one of various defined substituents. |
| priorityDate | 1982-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.