http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SE-8203914-L
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9433d383d1922b3df0ca6c182c7d3925 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-49 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-49 |
| filingDate | 1982-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43508013bc404d8255b4d93049362484 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24e5cae2a15ab3d5a19cb2152ff86cf2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85b0e0d4edee624c0b7521bc3da660b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_056cfd5ab17eddcad31295a4f8665dac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_283d9d77df4f89750f3351907e78cc1a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e78a6611a1be2245ac4ea9c8a0d7fa73 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62ecc223320877a9870a34e4c316a556 |
| publicationDate | 1982-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SE-8203914-L |
| titleOfInvention | PROCESS FOR THE PREPARATION OF 2,4-DIAMINO-5-(3ს,4ს,5ს-TRIMETHOXYBENZYL)-PYRIMIDINE |
| abstract | The invention relates to an improved process for the preparation of 2,4-diamino-5-(3',4',5'-trimethoxy-benzyl)-pyrimidine of the general formula I <IMAGE> by reacting a compound of the general formula II <IMAGE> (wherein R is an alkyl group having 1-4 carbon atoms) with guanidine, which comprises preparing the said compound of the general formula II by reacting alpha -(3,4,5-trimethoxy-benzal)- beta -methoxy-propionitrile of the formula III <IMAGE> with ethylene glycol monoalkylether of the general formula IV HO-CH2-CH2-OR (IV> (wherein R as as stated above) in the presence of an alkali metal alkoxide at a temperature between 60 DEG and 90 DEG and reacting the compound of the general formula II thus obtained - if desired without isolation - with guanidine in the presence of an alkanol having 4-8 carbon atoms. The advantage of the process is that it is economical and can be carried out with high yields even on industrial scale and provides a product of high purity. The compound of the formula I obtained is a known chemotherapeutical drug. |
| priorityDate | 1981-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.