| abstract |
The invention relates to 6-amino-2-penem-3-carboxylic acid compounds of the formula (I) in which R1a denotes hydrogen or an amino protective group R1A and R1b represents hydrogen or an acyl radical Ac, or in which R1a and R1b conjointly form a bivalent amino protective group, R2 denotes hydroxyl or a radical R2A which, together with the carbonyl grouping -C(=0)-, forms a protected carboxyl group, and R3 represents hydrogen or an organic radical which is linked via a carbon atom to the ring carbon atom, and 1-oxides thereof, as well as salts of such compounds having salt-forming groups, which compounds possess antibiotic properties, processes for the manufacture of such compounds, and also pharmaceutical formulations containing compounds of the formula I with pharmacological properties, and the use thereof, either as antibiotics, preferably in the form of pharmaceutical formulations, or as intermediate products. |