| abstract |
4,1-Benzoxazepines and thia analogs thereof of the formula: <IMAGE> (wherein -A-B- is the following group: <IMAGE> +TR <IMAGE> (wherein R1 is hydrogen, C1 to C3 alkyl, or C7 to C9 aralkyl; R2 is C1 to C3 alkyl or C1 to C3 alpha -aminoalkyl; R3 is C2 to C6 dialkylamino; R4 is C2 to C6 dialkylamino or C5 to C7 alkylpiperazino; R5 is C1 to C3 alkyl; and Q is oxygen or sulfur); D is oxygen or sulfur; X is halogen or nitro; Y is hydrogen or halogen; and Z is hydrogen, C1 to C3 alkoxy, or C3 to C9 dialkylaminoalkoxy; with the proviso that when -A-B- is <IMAGE> Z is not hydrogen.) useful as novel central nervous system drugs are prepared by various synthetic routes. |