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filingDate 1979-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 1980-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber SE-7907994-L
titleOfInvention CYTOTOXIC PRODUCT AND PROCEDURES FOR PRODUCING THEREOF
abstract Carcinostatic products are formed by coupling, by covalent bonding, the A chain of ricin with an antibody which is capable of selectively recognizing a given antigen at the surface of cancerous cells. Such products can be made by the formation of a disulphide bridge between the free thiol group in the A chain of ricin and an immunoglobulin or immunoglobulin fragment into which a thiol group or an activated disulphide group has been introduced. The A chain of ricin and the immunoglobulin are carefully purified before use.
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