| abstract |
Novel substituted aurones are of formula (I). In(I) R1R6 are each H, halogen C1-6alkoxy, C3-8 cycloalkyl, optionally substituted phenyl, amido, amino, cyano, hydroxy, nitro, C2-4 alkenyl, carboxyl, tetrazol-5-yl or-CH:CHCOOH; or R1 and R2 together are group of formula -CH:CH-CH:CH-; provided that at least one of R1-6 is carboxy, tetrazol-5-yl or -CH:CHCOOH. (I) and their salts and esters are effective in the prophylactic chemotherapy of allergic conditions such as bronchial asthma. dosages of 0.5-200(1-20) mg/kg per day may be administered. |