| abstract |
Novel 1,4-dihydropyridine derivatives of the formula: <IMAGE> are prepared by eliminating water from compounds of the formula: <IMAGE> which, for their part, are obtained from corresponding 2-methyl-1,4-dihydropyridines by reaction with hydroxylamine or with a salt thereof. R<1> denotes cyano or lower alkoxycarbonyl, R<2> and R<3> denote esterified carboxyl and R<4> denotes lower alkyl. The compounds have vasodilatory and hypotensive effects and can be used in the form of pharmaceutical preparations for treating high blood pressure and cardiovascular diseases. |