| abstract |
1530077 5 - Isothiocyanato - isoquinoline and uses thereof RHONE-POULENC INDUSTRIES 16 May 1977 [18 May 1976] 20557/77 Heading C2C The novel compound 5-isothiocyanato-isoquinoline is prepared by reacting 5-amino-isoquinoline with carbon disulphide and then N,N<SP>1</SP>-dicyclohexylcarbodiimide. The novel compound may be reacted with a 3 - hydroxmethyl - 1,2,3,4 - tetrahydroisoquinoline to form a 3-hydroxymethyl-N-(isoquinol - 5 - yl) - 1,2,3,4 - tetrahydroisoquinoline-2- carbothioamide, which in turn may be cyclized to a 3-(isoquinol-5-ylimino)-1,5,10,10a-tetrahydrothiazolo[3,4-6]-isoquinoline, which as the free base or an acid addition salt shows analgesic and antipyretic activity. |