http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SE-436423-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_97a285d8ecd0184a7e5d89a1e4e07997 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-52 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-34 |
| filingDate | 1981-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3fe97386c0f5967161d13b3e5e9443aa |
| publicationDate | 1984-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SE-436423-B |
| titleOfInvention | PROCEDURE FOR PREPARING 9-CYCLOHEXYL-2-ALCOXY-9H-ADENIN DERIVATIVES |
| abstract | The invention is a new procedure for producing 9-cyclohexyl-2-alkoxy-9H-adenine derivative with the formula<IMAGE>whereby R is alkyl with 1-6 carbon atoms. The procedure is unique in that one in order1) transforms 7-amino-5-(methyltio) (1,2,5) oxadiazolo (3,4-d) pyrimidine or 7-amino-5-(methyltio) (1,2,5) thiadiazolo (3,4-d) pyrimidine with 1-2 equivalent cyclohexylamine in an inert reaction solvent at a temperature of 20-130 degrees C to produce 7-/cyclohexylamino)-5-(methyltio) (1,2,5) oxadiazolo (3,4-d)-pyrimidine or 7-/cyclohexylamino)-5-(methyltio) (1,2,5) thiadiazolo (3,4-d)-pyrimidine2) reductively formulates the obtained compounds in 50-100 percent formic acid, whereby for the oxadiazolo compound one uses catalytic hydrogenation with palladium on carbon catalysts and for the thiadiazolo compound one uses Raney nickel to produce 4-amino-6-(cyclohexylamino)-5-(formylamino)-2-(methyltio) pyrimidine3) cycles the last-named compound with alkali metal hydroxide to produce 6-amino-9-cyclohexyl-2-(methyltio) purine4) oxidizes the last-named compound in an inert solvent to produce 6-amino-9-cyclohexyl-2-(methylsulfonyl) purineand5) constrict the methylsulfone group in the last-named compound with an alkali metal alkoxide with the formula RO-alk, whereby alk is sodium or potassium and R is an alkyl group with 1-6 carbon atoms, in an inert reaction solvent to produce a 2-alkoxy-9-cyclohexyladenine with formula I. |
| priorityDate | 1981-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 94.