http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SE-337828-B
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e45efeaa6a34dfd9d44fa29a7fe0c806 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D267-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D281-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D267-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D281-16 |
| filingDate | 1968-04-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3706fff8f1c6b5c5963d59b66f760535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b1f45cfa9dd93fa1c3501eeab5803a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b22935ecedb465a38bd76ad5f3ca6be |
| publicationDate | 1971-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SE-337828-B |
| abstract | 1,206,332. Dibenzo - oxazepines; - thiazepines; and -diazepines. YOSHITOMI PHARMACEUTICAL INDUSTRIES Ltd. 2 April, 1968 [8 April, 1967; 5 Feb., 1968], No. 15694/68. Heading C2C. Novel compounds of Formula (I) in which each of X<SP>1</SP> and X<SP>2</SP> is hydrogen, halogen, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylthio or trifluoromethyl, Y is -O-, -S-, -SO 2 - or -N(R)-, R being C 1-4 alkyl, Y is C 2-4 alkylene, and -N(R<SP>1</SP>)(R<SP>2</SP>) is C 1-4 alkylamino, di-(C 1-4 alkyl)- amino, cyclohexylamino, (phenyl-C 1-4 alkyl)-amino, piperidino, morpholino, 4-C 1-4 alkyl - 1 - piperazinyl or 4 - (hydroxy - C 1-4 alkyl)- 1 -piperazinyl, and acid addition salts thereof, are prepared by reacting a compound of Formula (II) with a compound of formula Q-NR<SP>1</SP>R<SP>2</SP>, in which one of P and Q is hydrogen and the other is -A-X<SP>3</SP> in which X<SP>3</SP> is halogen or organic sulphonyloxy, and if desired, salifying the product. Starting materials of Formula (II) are prepared by catalytic reduction of a compound of Formula (III) in which R<SP>3</SP> is C 1-4 alkyl, with hydrogen in the presence of Raney nickel, and, if necessary, reacting the resulting compound of Formula (II), in which P is hydrogen, with a compound of formula Ho-A-halogen or halogen-A- halogen, and, if necessary, esterifying the resulting compound with an organic sulphonyl chloride. Pharmaceutical compositions having histamine-, acetylcholine- and reserpine-antagonistic activity, for oral or parenteral administration, comprise a compound of Formula (I) or a pharmaceutically acceptable acid addition salt, together with a carrier. |
| priorityDate | 1967-04-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.