| abstract |
3,2-indole substituted as anti-inflammatory and analgesic agents for abstract pain. This invention provides a compound of the general formula: or pharmaceutically acceptable salts thereof wherein Z is OH, NR2R3, C1-6- or a different ring; Q is selected from the following: (A ) Optional substituted vinyl, (b) A six-member monocyclic aromatic group optionally substituted containing one, two, three or four atoms (atoms) nitrogen, (c) A five-member monocyclic aromatic group optionally substituted, containing one hetero atom selected from S, O and N and optionally contain 1,2 or 3 nitrogen atoms in addition to the mentioned hetero atom, (d) Optional C3-7 substituted and (e) a heterocyclic ring combined with optionally substituted benzo; R1 is hydrogen, the alkali is C1-4 or halo; R2 and R3 are separately hydrogen, OH, the coxy C1-4, the alkyl C1-4 or the alkyl C1 -4 replaced by BALO, OH, KCI-C1-4 or CN; X is selected separately from H, HALO, Alkyl C1-4, Alkyl C1-4 replaced by BHALO, OH, KOXI C1-4, KOCI-C1-4 replaced by BHALO, thioalkyl NH2, NO2, C1-4, bis- (alkyl C1-4) amino and CN; n is zero, 1, 2, 3 and 4. This invention also provides a useful pharmacological composition for the treatment of a medical condition in which prostaglandins are involved as disease generators. |