http://rdf.ncbi.nlm.nih.gov/pubchem/patent/SA-119400336-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bbd1d44888f5b41142d83de455096387 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-365 |
| filingDate | 2019-01-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edd60367ab622b2333eff2adab8a2bbd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da35699c11bc700ae84bd1373b105b52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2106e3c7965524a6d6e354b6cb181b37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61a3c3a79b93ef74a5b323be1689f29c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b09d1486fe641159686acf44e772f10b |
| publicationDate | 2021-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | SA-119400336-B1 |
| titleOfInvention | -Isandrographolide-19 (NAFLD) propionate for the treatment of nonalcoholic fatty liver disease |
| abstract | The present invention relates to isoandrographolide-19-propionate for the treatment of non-alcoholic fatty liver disease (NAFLD) related to isoandrographolide-19-propionate (IAN-19P), having the structural formula : and its medicinally acceptable salts. The compound is created by reacting isoandrographolide with anhydrous propionic acid in the presence of N,N'-dicyclohexylcarbodiimide, N'-dicyclohexylcarbodiimide and 4-dimethylaminopyridine. Laboratory testing shows that isoandrographolide has lower toxicity than andrographolide, but has significantly elevated activity at 50 mM concentration. IAN-19P produces normal triglyceride levels and significantly reduces lipoperoxide formation in steatotic HepG2 cells induced with palmitate-oleate, and also reduces the leakage of alanine transaminase ALT from treated cells. |
| priorityDate | 2018-01-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.