| abstract |
New compounds of the formula in which R is H, CH, OCH, NO, NH, CH, CF, CHF, CHF or halogen, R is a heterocyclic radical selected from 1-imidazolyl, triazolyl, tetrazolyl, pyrazolyl, pyrimidinyl, oxazolyl, thiazolyl , isoxazolyl and isothiazolyl, R represents H or OH, R represents H, R represents H or OH or R represents H and R and R together form a bond, or R represents hydrogen and R and R together form = O, R represents methylene, ethylene, -CHOH -CH-CHOH-, -CHOH-CH-, -CH = CH- or -C (= O) -, or R is H and R and R together form = CH- or = CH-CH-; their stereoisomers and non-toxic pharmaceutically acceptable salts with acids possess selective aromatase-inhibiting properties compared to their desmolase-inhibiting properties. The compounds of the invention are suitable for the treatment of extragenzavisimy diseases, such as breast cancer or benign prostatic hyperplasia (BPH). |