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filingDate 1992-12-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb80263932d332068d8651e84b31e925
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publicationDate 1996-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-94030499-A
titleOfInvention Tetrahydroisoquinoline compounds, their o-acylated derivatives, method of synthesis, pharmaceutical composition, method of treatment
abstract Tetrahydroisoquinoline compounds of the formula I and their pharmaceutically acceptable salts, in which: R represents one or more substituents selected from H, halogen, hydroxy, alkyl (optionally substituted hydroxy), alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, nitro, cyano, polyhaloalkyl, polygaloalkyl phenyl (optionally substituted with one or more halogen, alkyl or alkoxy), or R is carbonyl optionally substituted with carbomoyl; R represents an aliphatic group optionally substituted with hydroxy or alkoxy; E represents an alkylene chain optionally substituted with one or more alkyl groups; G is phenyl or phenyl substituted with one or more alkyl, alkoxy, halogen, hydroxy, polyhaloalkyl, polyhaloalkoxy cyano, alkylthio, alkylsulfinyl, alkylsulfonyl, phenyl (optionally substituted with one or more halogen, alkyl or alkoxy), optionally alkyl carbomoyl or G represents a phenyl ring having a heterocyclic or aromatic ring fused to it; 0 - acylated derivatives representing lyophilic esters, which are used in analgesia and in the treatment of psychoses (e.g. schizophrenia), Parkinson's disease, Lesch-Nyan syndrome, impaired attention deficit or impaired cognitive ability, or to alleviate drug dependence or delayed dyskinesia.
priorityDate 1991-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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Total number of triples: 36.