http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-94028194-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_66c2cb078235b6f346489e04c59cadfe |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D207-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-02 |
| filingDate | 1994-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_963251a7950b7d83ab120a030af646af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ad7019df45d10fe9ba0e8fad6411c3d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf49a8ac3101dc88e30db18829f24308 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f5a2e18aa4b34937fbb06fffc8ebdf3 |
| publicationDate | 1996-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-94028194-A |
| titleOfInvention | 4-acetyl-5-n-iodophenyl-1-carboxymethyl-3-hydroxy-2,5-dihydropyrrole-2- -on possessing analgetic activity |
| abstract | 4-acetyl-5-p-iodophenyl-1-carboxymethyl-3-hydroxy-2,5-β-dihydropyrrol-2-one formula can be used in medicine as an analgesic. It is prepared by reacting methyl ester of acetylpyruvic acid, glycol and p-iodobenzaldehyde at room temperature according to the scheme CHCOCHCOCOOCH + NHCHCOOH + Yield 71%. T286 - 288 ° C (with decomposition). Found,%: C 41.80; H 3.00; N, 3.45; J 31.60. CHNOJ. Calculated,%: C 41.87; H 3.01; N 3.49; J 31.65. The analgesic activity of compound 35.4 exceeds that of the analog compound and the orthophene standard by 2 times. The toxicity of the compound is 2500 mg / kg, which is 2 times less than the toxicity of the analogue and 6.6 times less than the toxicity of orthophene. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2485100-C1 |
| priorityDate | 1994-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 25.