http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-47645-U1
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| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61B17-00 |
| filingDate | 2005-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2005-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2005-09-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-47645-U1 |
| titleOfInvention | DEVICE FOR TRANSMEMBRANE ADMINISTRATION OF MEDICINES IN THE BRAIN TISSUE |
| abstract | The invention relates to medicine, namely to neurosurgery, and can be used for local injection of drugs into pathological zones of brain tissue for contact exposure to the focus.n n n The objective is to reduce the harmful effects of drugs on viable brain tissue, reduce the degree of resorptive effects on the body, control the concentration of the substance.n n n The task is carried out using a method and device for transmembrane administration of drugs to the brain.n n n In our work, we used membrane injection systems based on semipermeable cellophane capsules with pore diameters from 1.5 to 3 nm.n n n The system consisted of two main parts — a semipermeable capsule and two polyvinyl chloride catheters, through which a solution of a medicinal product was supplied, and spent dialysate was discharged. The length of the catheters was selected empirically depending on the type of pathological process, the estimated time of exposure, the technical conditions of administration. Empirically selected average size of catheters -770mm. A feature of catheters is the presence of end threads (internal and external, respectively), allowing you to create a closed loop and in the early postoperative period to prevent rapid dislocationn n n brain, the subsidence of the walls of a semipermeable capsule, the possibility of creating a depot of the drug, and also simplify the connection to the infusomat system. The second main part of the system is a semipermeable capsule. The size of the capsule is variable, depending primarily on the size of the lesion. The working surface of the capsule has a folded shape, which improves contact with the surface of the brain. The supply of the drug (methetrexate at a dose of 10 mg was used) dissolved in polyglucin (dextran is a glucose polymer and is produced by Leuconostoc Mesenteroides bacteria when grown on a medium containing sucrose).n n n Sterilization of the prepared membrane capsules was carried out in a 1% solution of chlorhexidine bigluconate (at least 30 minutes), followed by storage in a 1: 5000 solution of furacilin. With this method of sterilization, crops from microflora growth membranes do not give in 100% of cases [I].n n n Intraoperatively, after total or subtotal removal of the tumor, a semipermeable capsule was placed in its bed, catheters were brought out through the milling hole and fixed to the skin. The tank was filled with furacilin.n n n The introduction of metatrexate dissolved in polyglucin began on the second day after surgery and lasted for 12 hours, three days in a row. The spent dialysate was collected in a tank and the volume was compared with the initial volume, which made it possible to judge the degree of brain dehydration.n n n Careful monitoring of the patient’s condition during the entire time of drug administration showed satisfactory tolerance of the procedure with a moderate general reaction of the body in the form of a temperature increase of 1.5-2 ° C from the initial, increased headache, dyspeptic manifestations.n n n Observation of patients after discharge, with an analysis of MRI studies, showed prolongation of life, a significant regression of neurological symptoms, and the absence of continued growth at the surgical site, which suggests the effectiveness of this method and recommend it for use in the combined treatment of malignant brain tumors.n n n 1. Grakov B.S., Selezov E.A., Shvetsky A.G. Semi-permeable membranes in the treatment and prevention of surgical infection (wound management). - Krasnoyarsk: Publishing House of Krasnoyarsk Un-ta, 1988. - 160p.n n n Used Books:n n n 2. Grakov B.S., Selezov E.A., Shvetsky A.G. Semi-permeable membranes in the treatment and prevention of surgical infection (wound management). -Krasnoyarsk: Publishing House of Krasnoyarsk Un-ta, 1988.160s.n n n 3. Kapsargin F.P. The use of transmembrane dialysis and intravenous laser irradiation of blood in the treatment of primary acute purulent pyelonephritis: Abstract. Dis .... Candidate of Medical Science. -Krasnoyarsk, 2000. -22s.n n n 4. Kuzin M.I., Kostyuchenko B.M. Wounds and Wound Infection: A Guide for Physicians. -M .: Medicine, 1990. -P.592n n n 5. Sychev G.M. Experimental and clinical development of extraocular transmembrane dialysis:n n n Aftoref.diss .... Candidate of Medical Science.-Krasnoyarsk, 1988.-23s.n n n 6. Yavisya A.M. The use of diffuse-separation processes on a semipermeable membrane in the treatment of peritonitis: Abstract. diss .... candidate of medical science. - Krasnoyarsk, 1993. -28s.n n n 7. Selezov EA Prevention and treatment of wound infections in open and gunshot fractures of the tubular bones using diffuse-dividing membrane processes:n n n diss .... doctor of medical science.-L., 1986.-297s.n n n 8. Laka A.A. Treatment of injuries caused by rail using transmembrane dialysis:n n n Diss .... Candidate of Medical Science. -Krasnoyarsk, 1991._ 187s. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2479268-C2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2574990-C2 |
| priorityDate | 2005-02-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 25.