http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2771239-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_32725e94a005113e476561f08f21ac4e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-15 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N30-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 |
| filingDate | 2021-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_524c15ac144afe39f80649b909af5c5b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2d67b4468856aa3b9be5454cf5b933d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7038544a0aa132de5971e9a65682d0fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7d8591221d473c1400c9e67be0aa050 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_996cb7826b2c5464aa3617909ac501df |
| publicationDate | 2022-04-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2771239-C1 |
| titleOfInvention | Method for the quantitative determination of 1,4-dihydro derivatives of 1,2,4-benzothiadiazine-1,1-dioxide |
| abstract | FIELD: chemistry.SUBSTANCE: method for the quantitative determination of 1,4-dihydro derivatives of 1,2,4-benzotidiazine-1,1-dioxide, including dissolution of the analyzed sample at room temperature and stirring, treatment of the aliquot part of the prepared solution with chemical reagents: SnCl2solution in a strongly acidic medium, interaction of the obtained sulfhydryl compounds with sodium nitroprusside in an alkaline solution, followed by photoelectric colorimetry of the obtained colored solutions, quantitative determination of the target substance according to the calibration schedules, characterized in that the exact weights of chlorothiazide, bendrosflumethiazide, benzothiazine, cyclomethiazide or hydrochlorothiazide are dissolved in DMFA, the aliquot part of chlorothiazide, bendrosflumethiazide and benzothiazole, cyclomethiazide or hydrochlorothiazide is treated with a 2-3-fold excess relative to the detectable component of 0.01 Μ SnCl2solution in concentrated HCl, and then hot concentrated HCl to create a pH of 4-5 and boil for 20 minutes, then cooled to room temperature temperatures and H2O is added and hot concentrated HCl in a volume ratio of 1:1 to create a pH of 4-5, they are kept for 2 minutes at a temperature of 30-40°C on a water bath and cooled to room temperature, 0.01 Μ aqueous solution of NaOH is added to a pH of 8-10 and drop by drop, gradually an excess relative to the determined component of an aqueous solution of sodium nitroprusside is added to 0.1 Μ KOH, kept for 2 minutes, 5% aqueous solution (NH4)2SO4is added as a stabilizer in a volume ratio of 1:30 with respect to an aqueous solution of sodium nitroprusside in 0.1 Μ KOH, the optical density of colored solutions is measured on a photoelectric colorimeter at 490 nm, the comparison solution is a solution of sodium nitroprusside in 0.1 Μ solution of KOH.EFFECT: expansion of the range of methods for quantitative determination of 1,4-dihydro derivatives of 1,2,4-benzotidiazine-1,1-dioxide.1 cl, 5 dwg |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2800907-C1 |
| priorityDate | 2021-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.