http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2770404-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3d9bc91df72f42df9e973f969e9febc3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5025 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5025 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-06 |
| filingDate | 2017-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_445b2b6a90ad236c182acd24f5095c60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dd1dd2e12b481ed2b8123c6ee20e14f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c8704f18f49b2170684770f9ecd79cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb9921c1ba83641829419e4724994a30 |
| publicationDate | 2022-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2770404-C2 |
| titleOfInvention | Traf 6 inhibitors |
| abstract | FIELD: organic chemistry. n SUBSTANCE: invention relates to the field of organic chemistry, namely, to an application of a compound by the formula (I) for inhibiting interaction of TRAF6 with UBC13, wherein X is selected from the group consisting of N and CH; R 1 is selected from the group consisting of hydrogen, a (C 1 -C 6 )alkyl, a (C 1 -C 6 )halogenalkyl; R 2 and R 3 are independently selected from the group consisting of a linear (C 1 -C 6 )alkyl; n constitutes 2; Z is selected from the group consisting of C=O; Z is C=O; A is selected from the group consisting of –N(R 4 )(R 5 ) and R 4 constitutes hydrogen or a (C 1 -C 6 )alkyl; R 5 is selected from the group consisting of a (C 6 -C 10 )aryl(C 1 -C 6 )alkyl, a furanyl(C 1 -C 6 )alkyl, a thiophenyl(C 1 -C 6 )alkyl, and an indolyl(C 1 -C 6 )alkyl, optionally substituted with one or more identical or different substituents selected from the group consisting of halogen, a (C 1 -C 4 )alkyl; R 6 constitutes a (C 1 -C 4 )alkyl; Y is selected from the group consisting of N-B, CH-B, and O; B is selected from the group consisting of a (C 6 -C 10 )aryl, pyridinyl, a (C 6 -C 10 )aryl(C 1 -C 6 )alkyl, a pyridinyl(C 1 -C 6 )alkyl, a furanyl(C 1 -C 6 )alkyl, and a (C 1 -C 6 )alkyl, optionally substituted with one or more identical or different substituents selected from the group consisting of halogen, a (C 1 -C 4 )alkyl, a (C 1 -C 4 )halogenalkyl, and -OR 6 ; p and q constitutes an integer from 1 to 2. The invention also relates to a compound by the formula (I), wherein the values of radicals have the values specified in the claim, and specific compounds. n EFFECT: inhibition of interaction of TRAF6 with UBC13 by a compound by the formula (I) in treatment of arthritis, psoriasis, and some types of cancer. n n n n 12 cl, 20 dwg, 2 tbl |
| priorityDate | 2016-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1169.