| abstract |
FIELD: pharmaceutics.SUBSTANCE: invention relates to a compound of formula A-B-C (I), where A is; B is -(C2-C6)-alkylene-C(O)N(R)-; C is; R is H; R1is independently H, (C1-C6)alkyl or CF3; R2is H, (C1-C6)alkyl, substituted or unsubstituted (C6)aryl, (C3-C6)cycloalkyl, -(C2-C6)alkylene-(C1-C6)alkoxy, (C1-C6)alkylene-(C6)aryl, substituted or unsubstituted pyridinyl, indolyl or 2,3-dihydrobenzofuranyl; R3is H or a halide; R6and R7independently represent H or a halide; and n' is independently 0, 1 or 2; or a pharmaceutically acceptable salt thereof. Also disclosed is a pharmaceutical composition.EFFECT: disclosed compounds are low-molecular integrin inhibitors αvβ6 and can be used to treat a number of diseases and pathological conditions.31 cl, 1 dwg, 34 ex |