| abstract |
FIELD: medicine. n SUBSTANCE: invention relates to a compound having structure I or its pharmaceutically acceptable salt that inhibit fatty acid synthase (FASN) and that can be used in the treatment of cancer. In the formula I, L-Ar is or ; Ar is ; R 1 is -CN or -O-(C 1 -C 4 alkyl) optionally substituted with one or more halogens; each R 2 is hydrogen; R 3 is H or F; R 21 is C 1 -C 4 alkyl; R 22 is H or C 1 -C 2 alkyl; R 24 is -O-(C 1 -C 4 alkyl), -O-(C 1 -C 4 alkyl)-O-(C 1 -C 4 alkyl) or -O-(4-6-element heterocycle), wherein R 24 is optionally substituted with one or more hydroxyls or halogens; and R 25 is C 1 -C 4 alkyl. The invention also relates to a pharmaceutical composition containing the specified compounds and a method for treatment of cancer characterized in violation of regulation of a fatty acid synthase path. n EFFECT: obtaining a compound for the treatment of cancer. n n n n 26 cl, 2 tbl, 2 ex |