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filingDate 2017-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09e7413b876f5e3131d7db2e76e4d986
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publicationDate 2022-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2764573-C2
titleOfInvention Improved synthesis of lysine acetylsalicylate and glycine particles
abstract FIELD: chemistry.SUBSTANCE: present invention relates to a method for producing particles of lysine acetylsalicylate-glycine, including stages of a) providing a solution of acetylsalicylic acid in ethanol; b) providing an aqueous solution of lysine; c) combining solutions from stages (a) and (b) to obtain a mixture; d) mixing the resulting mixture; e) adding acetone to the mixture; f) incubating the mixture with the possibility of the formation of a product of acetylsalicylic acid lysinate; g) isolating the product of acetylsalicylic acid lysinate; wherein acetylsalicylic acid is used in excess relatively to lysine, and wherein seed crystals are not added to the mixture; and h) providing recrystallized glycine, where glycine is recrystallized using following stages: h1) dissolving glycine in water; h2) adding acetone to the glycine solution; h3) mixing the resulting mixture until a precipitate is obtained; i) combining recrystallized glycine from the stage (h) with the product of the stage (g) acetylsalicylic acid lysinate with the production of lysine acetylsalicylate-glycine particles (LASAG).EFFECT: improved synthesis of lysine acetylsalicylate-glycine particles.15 cl, 9 dwg, 1 tbl, 4 ex
priorityDate 2016-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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