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filingDate 2017-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf314cd4e4f0b572cfc8eeb4d9d89ea4
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publicationDate 2022-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber RU-2764443-C2
titleOfInvention Transdermal therapeutic system containing azenapine and polysiloxane or polyisobutylene
abstract FIELD: medicine.SUBSTANCE: invention relates to options of a transdermal therapeutic system for transdermal delivery of azenapine and a method for obtaining a layer containing azenapine for use in the transdermal therapeutic system. The transdermal therapeutic system contains a self-adhesive layered structure containing the therapeutically effective amount of azenapine. The self-adhesive layered structure contains: A) substrate; B) a layer containing azenapine, containing: 1. azenapine in the form of a free base; and 2. polymer selected from a group consisting of polysiloxanes in the amount of more than 50% by weight per the total weight of the layer containing azenapine; and C) optionally, an additional layer contacting with the skin. The layer containing azenapine contains a crystallization inhibitor in the amount from 0.5 to 10% by weight per the total weight of the layer containing azenapineEFFECT: obtaining a transdermal therapeutic system of a matrix type for transdermal azenapine injection, providing a penetration speed that is sufficient for achieving a therapeutically effective dose.15 cl, 13 ex, 13 tbl, 13 dwg
priorityDate 2016-12-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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