http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2763544-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c6621e8655d8a7b67a7fd011deb0416e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0053 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2018-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6c292de97b1013fc6b62d27bb4f5234f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1018cb11a164183b4e53167e19731a4d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd7f6efc290b8452906d2daaba011edf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ccb0c1ac0a6f1c176cbcfaf29691dcce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a229d327a6f7cd6a8ca0c93f4e1b694b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b59855c67c5057e7c47563adfc54ab8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82487c391b4cca3157f5fd9d5e3d5ff6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8832302da86238f8f2060ef36e5dbe5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b156071f45faad5b782eea42dff0f35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12f083ac7f10981ff7293f6104185ace http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bada51ecc43f5bda4a86d3ecffcc2867 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62fdd7f2501e13533dfc04f3d86f0541 |
| publicationDate | 2021-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2763544-C2 |
| titleOfInvention | Combination of mcl-1 inhibitor and taxane compound, their applications and pharmaceutical compositions |
| abstract | FIELD: medicine; pharmaceutics.SUBSTANCE: first invention is a combination for the treatment of mammary gland cancer or lung cancer, containing: (a) MCL-1 inhibitor, which is (2R)-2-{[(5Sa)-5-{3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl]oxy}-3-(2-{[1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]methoxy}phenyl)propanoic acid or (2R)-2-{[(5Sa)-5-{3-chloro-2-methyl-4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl}-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy}-3-(2-{[2-(2-methoxyphenyl)pyrimidin-4-yl]methoxy}phenyl)propanoic acid, or their enantiomers, diastereoisomers, atropisomers or their addition salts with pharmaceutically acceptable acid or base, and (b) a taxane compound, which is paclitaxel or docetaxel, for simultaneous, sequential or separate use. The group of inventions also includes: the specified combination for the use for the treatment of mammary gland cancer or lung cancer; a pharmaceutical composition containing the specified combination with one or several pharmaceutically acceptable fillers; the use of the specified combination for the preparation of a drug for the treatment of mammary gland cancer or lung cancer; a drug separately or jointly containing the specified combination components; a method for the treatment of mammary gland cancer or lung cancer, including the injection of the specified combination; and a method for the sensitization of a patient, including the injection of the specified combination.EFFECT: group of inventions provides for the synergetic action of the combination of MCL-1 inhibitor and taxane compound.24 cl, 4 tbl, 9 ex |
| priorityDate | 2017-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 175.