| abstract |
FIELD: pharmaceutics. n SUBSTANCE: present invention describes a chloroquine gel, a method for its manufacture and application, as well as chloroquine nano-microspheres, including a water-soluble nano-microsphere carrier and chloroquine or a chloroquine derivative. The ratio of the mass of chloroquine or chloroquine derivative to the mass of the water-soluble carrier of nano-microspheres does not exceed 1:3. In accordance with the present invention, water-soluble nano-microspheres are used to produce nano-microspheres together with chloroquine or chloroquine derivatives, which effectively solves the problems of side effects and drug resistance to chloroquine; this prolongs the time spent on the problem area of the drug, improves the bioavailability and therapeutic effect of the drug, effectively treats infectious diseases of the external genitalia and significantly increases the therapeutic effect; also, not only expands the scope of application, but also the scheme of application of chloroquine. n EFFECT: method for its preparation is simple, it is easily synthesized, has no toxic side effects, is safe, can be used in the industrial production of new drugs. n 10 cl, 9 dwg, 2 tbl, 10 ex |