| abstract |
FIELD: medicine. n SUBSTANCE: invention relates to a compound of the formula III or its pharmaceutically acceptable salt, which can be used for the treatment of neurodegenerative diseases. In the formula III, R 4 is selected from H and C 1-6 alkyl, and R 3 is: (a) H, OH, NH 2 , C 2-6 alkenyl, C 2-6 alkynyl, C 3-6 cycloalkyl or 3-6-element heterocyclic ring containing one heteroatom selected from O; or (b) C 1-6 alkyl optionally substituted with 1, 2 or 3 substituents, each of which is independently selected from OH, halogen, NH 2 , -SO 2 H, -SO 2 (C 1-6 alkyl), CN or phenyl group optionally substituted with 1, 2 or 3 substituents, each of which is independently selected from a group consisting of OH; or (c) -O-C 1-6 alkyl; or (d) phenyl group optionally substituted with 1, 2 or 3 substituents, each of which is independently selected from a group consisting of OH, NO 2 and halogen. Proposed compounds have improved penetration through a blood-brain barrier. The invention also relates to specific compounds and a pharmaceutical composition containing the specified compounds. n EFFECT: obtaining compounds for the treatment of neurodegenerative diseases. n n n n formula III n 25 cl, 2 dwg, 1 tbl, 32 ex |