http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2759377-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4bbe2fe4f04b40fe8f6b1b75e3f8bb21 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 |
| filingDate | 2020-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ea4d1627b8c2fcaa68ce3ef07199452 |
| publicationDate | 2021-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2759377-C1 |
| titleOfInvention | Method for producing a highly purified tetradecapeptide |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to peptide and pharmaceutical chemistry, namely to a method for producing a tetradecapeptide H-Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu-OH by the reaction of condensation of a pentapeptide by the formula Boc-Thr-Glu(OtBut)-Lys(Boc)-Lys(Boc)-Arg-OH with a nonapeptide with a free amino group by the formula H-Arg-Glu(OtBut)-Thr-Val-Glu(OtBut)-Arg-Glu(OtBut)-Lys(Boc)-Glu(OtBut)-OtBut, wherein the pentapeptide Boc-Thr-Glu(OtBut)-Lys(Boc)-Lys(Boc)-Arg-OH is produced from arginine by subsequent addition of N-succinimidyl ether of Nα-carbobenzoxy-Nε-tert-butyloxycarbonyl-L-lysine, N-Succinimidyl ether of Nα-carbobenzoxy-Nε-tert-butyloxycarbonyl-L-lysine, N-succinimidyl ether of Nα-carbobenzoxy-γ-tert-butylglutamine acid and pentafluorophenyl ether of N-tert-butyloxycarbonyl-L-threonine, and the nonapeptide is produced by condensation of a pentapeptide Z-Glu(OtBut)-Thr-Val-Glu(OtBut)-ArgOH with a tripeptide with a free amino group by the formula H-Glu(OtBut)-Lys(Boc)-Glu(OtBut)-OtBut followed by condensation with protected arginine. n EFFECT: method ensures production of a highly purified tetradecapeptide with an increased yield of the finished product. n 5 cl, 3 dwg, 1 ex |
| priorityDate | 2020-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 105.