abstract |
FIELD: biotechnology.SUBSTANCE: present invention relates to biotechnology, namely to a genetically recombinant smallpox vaccine virus that is effective for the prevention or treatment of cancer. The smallpox vaccine virus contains two polynucleotides, polynucleotide encoding IL-7 and encoding IL-12. The virus has oncolytic activity. The pharmaceutical composition contains the smallpox vaccine virus and is used for the prevention or treatment of cancer.EFFECT: smallpox vaccine virus causes complete remission and acquired immunity.15 cl, 8 dwg, 8 tbl, 8 ex |