http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2756507-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J23-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J27-128 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2018-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f6dc9e117261e0cc652fc2bf8e7c9b4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ce68dbdef4b6f694ce56db1ec3f6119 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5a2dccd320dc953396c53c51d588eecc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e65ac23fe2ac07cc3745246feb851f6a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_306ae3bd88076068966b862a0d30c1b1 |
| publicationDate | 2021-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2756507-C2 |
| titleOfInvention | Method for preparing 1-(4-methanesulfonyl-2-trifluoromethylbenzyl)-2-methyl-1h-pyrrolo[2,3-b]pyridine-3-yl-acetic acid |
| abstract | FIELD: chemistry.SUBSTANCE: invention relates to methods for producing 1-(4-methanesulfonyl-2-trifluoromethylbenzyl)-2-methyl-1H-pyrrolo[2,3-b]pyridine-3-yl-acetic acid (Compound A). The first producing method consists in the interaction of a compound of the formula C9 with dimethyl ether of diazomalonic acid (DMDA) in the presence of a catalyst and an organic solvent to form a compound of the formula C10. Then, a reaction of the compound of the formula C10 with a strong base/acid is carried out to obtain the Compound A. The second synthesis method includes a reaction of the compound of the formula C9 with halogen to form a compound of the formula C11. The resulting compound of the formula C11 is subjected to interaction with dimethylmaleate to form the compound of the formula C10, which is converted into the Compound A by the above-mentioned method.EFFECT: methods consist of a smaller number of stages, allow one to achieve higher yield of the product and have higher selectivity for the Compound A.,,,18 cl, 1 dwg, 37 ex |
| priorityDate | 2017-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 100.