| abstract |
FIELD: pharmaceutics.SUBSTANCE: in the present claim, a solid lyophilized vaginal dosed form is disclosed that can contain the effective amount of acyclovir, a crystal structure-forming agent that is mannitol in the amount of about 5 wt.% to about 40 wt.% per the total weight of the lyophilized dosed form, and at least one substance forming a polymer mucoadhesive matrix. The dosed form can have pH of about 4.0-5.0 and can disintegrate within 120 seconds after it comes into contact with vaginal mucosa. A method for delivering an active ingredient to vaginal mucosa using an open solid dosed form is also described.EFFECT: obtaining lyophilized pharmaceutical compositions for vaginal delivery.12 cl, 12 dwg, 12 ex, 2 tbl |