http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2753036-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3cda15f265e0b7dfe3b6f8744ec97ce3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J73-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-585 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J73-003 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J73-00 |
| filingDate | 2018-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c00119c929149e466956311ede78438d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b991878cb69856e92b85aa57fe6c699 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_190bd8841a518757e75fd8d390218800 |
| publicationDate | 2021-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2753036-C1 |
| titleOfInvention | Tryptolide derivative, method for its preparation and application |
| abstract | FIELD: pharmacology.SUBSTANCE: invention relates to a compound represented by the formula I, or its pharmacologically acceptable salt, where R1is a substituted or unsubstituted group selected from a group consisting of a phenyl and a 5-membered heteroaryl containing 1 heteroatom selected from O; Y is O; R2is -C (=O)R4, where R4is a substituted or unsubstituted group selected from a group consisting of cyclohexyl, phenyl and a 5-membered heteroaryl containing 1 heteroatom selected from O;is a double bond or a single bond, and when it is a double bond, R3represents O, when it is a single bond, R3represents OR5or F, while R5represents H, Boc, CH2SCH3, -CH2OP(=O)(OH)2or -CH2OP(=O)(OBn)2; each X represents H; each of the above terms “substituted” independently means that one hydrogen atom in the group is replaced by a substituent selected from a group consisting of a halogenated C1-C8 alkyl and an unsubstituted C1-C8 alkoxy. The invention also relates to methods for obtaining these compounds and to a pharmaceutical composition that has an immunosuppressive and antitumor effect, based on them.EFFECT: obtaining new compounds and a pharmaceutical composition based on them, which can be used in medicine for the treatment of tumor diseases.I9 cl, 2 dwg, 4 tbl, 13 ex |
| priorityDate | 2018-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 122.