| abstract |
FIELD: medicine; pharmaceuticals.SUBSTANCE: group of inventions relates to the field of medicine and pharmaceuticals. The 1st object is a pharmaceutical composition containing particles containing at least 95 wt % taxane selected from paclitaxel and docetaxel, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, while these paclitaxel particles have a specific surface area (SSA), measured by the Brunauer-Emmet-Teller (BET) method, from 18 m2/g to 40 m2/g and an average volume density from 0.050 g/cm3to 0.12 g/cm3and these docetaxel particles have an SSA measured by the BET method of 18 m2/g to 50 m2/g and an average volume density of 0.050. The 3rd object is a method for producing particles containing at least 95 wt % taxane selected from paclitaxel and docetaxel.EFFECT: increased solubility of paclitaxel or docetaxel particles with increased specific surface area and reduced volume density.19 cl, 10 dwg, 5 tbl, 1 ex |