http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2746816-C2
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b435b2eefd6efa716b579fe50ce7d4f2 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0278 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-027 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-00 |
filingDate | 2019-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2021-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69db09b41f88307d8e32911af4ec41be |
publicationDate | 2021-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | RU-2746816-C2 |
titleOfInvention | Humanized mice (htnfki/htnfr2ki) on c57bi /6 genetic basis with additional capability of htnfr2 conditional removal for biomedical research |
abstract | FIELD: biochemistry.SUBSTANCE: invention relates to the field of biochemistry, in particular to the study of the mouse genome, which contains in the mouse locus TNFR2 gene containing human exons 2 to 6, encoding the extracellular part of human TNFR2 binding to human TNF, with the possibility of conditionally blocking the activity of the TNFR2 gene in cells expressing cre-recombinase. A method for studying the activity of therapeutic agents that bind to human TNF, including introduction of such agents to the above-mentioned mouse, is also disclosed. The invention also relates to a method for studying the activity of therapeutic agents of agonists and antagonists binding to human TNFR2, including introduction of such agents to the above mouse.EFFECT: invention is effective in the study of the properties of drugs used in treatment of autoimmune diseases.4 cl, 2 tbl, 4 ex, 3 dwg |
priorityDate | 2019-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 360.