| abstract |
FIELD: medicine.SUBSTANCE: set of inventions relates to medicine, in particular to veterinary medicine, and can be used for producing compositions for controlling the infection of the foot and mouth disease virus (FMDV) in animals. For this purpose, a recombinant viral vector expressing the foot and mouth disease virus antigen (FMDV) which forms viral-like particles or empty capsids FMDV is produced, wherein the above-mentioned FMDV antigen is a modified polypeptide P1 which forms a disulfide bridge, which is a consequence of the modification of polypeptide P1 by cysteine substitution in a position corresponding to 179 amino acid in SEQ ID NO: 2, 6, 8, 10 or 16, and said viral-like particles or empty capsids FMDV have increased thermal and acid resistance. Set of inventions also relates to a composition for inducing an immune reaction in an animal against FMDV, which comprises a recombinant viral vector, to a plasmid expressing FMDV antigen, and to an insect cell which is stabilized by said plasmid.EFFECT: use of this set of inventions enables producing viral-like particles or empty FMDV capsids exhibiting increased thermal and acidic resistance, providing levels of protection against contamination with homologous and heterologous FMDV.19 cl, 26 dwg, 11 tbl, 14 ex |