http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2744168-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_796aeceacdf829e095c7558e86ed711d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2018-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83f98038b0d0e447ce87e8e79fabb4e9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41f5fc1abd95c46389bb18d05277d216 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e113c76df23800b18f553d02c1bbc67 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83dadfc36adb3b943f1c54a3eecb18d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c093ca71136883cc64b57d0a0f40c933 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82dcb2b78ce94f8c32b4573bc1369685 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1e4e83ef1a2696cbfa62bad651ea9bea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_306e0a6be44c64a89bbfac1f7a963161 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_935226a564d24ad3d3d84bc255b282cf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2f4b3afebc7d4cdeeb778f9129edfab1 |
| publicationDate | 2021-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2744168-C1 |
| titleOfInvention | New pyrimidine derivative with an effect of inhibiting growth of cancer cells and pharmaceutical composition containing it |
| abstract | FIELD: chemistry, medicine. n SUBSTANCE: present invention relates to a new pyrimidine derivative. New pyrimidine derivative is represented by chemical formula 1, or a pharmaceutically acceptable salt thereof, where X and Y each independently appear as carbon or nitrogen, Z represents oxygen or C1-C4 alkyl group, R 1 is C1-C4 alkyl group, C3-C6 cycloalkyl group, CF 3 or dimethylamino group, R 2 represents C1-C4 alkyl group, R 3 is hydrogen or halogen group, R 4 represents hydrogen, halogen group, CN, CF 3 , C1-C4 alkyl group or aminocarbonyl group, R 5 appears as hydrogen or C1-C4 alkyl group a group, R 6 is C1-C4 alkyl group, R 7 presents hydrogen, amino group substituted with one or more C1-C4 alkyl groups, or piperazinyl group, unsubstituted or substituted with one or more C1-C4 alkyl groups, when Z is oxygen, Z forms a double bond with S, which forms a single bond with N, or when Z represents C1-C4 alkyl group, Z forms a single bond with S, which generates a double bond with N; and R 4 and R 5 can also be bonded to form pyrrole, imidazole or thiophene. The invention also relates to the pharmaceutical composition for lung cancer treatment and containing an effective amount of the compound represented by Formula 1 or pharmaceutically acceptable salt thereof. n EFFECT: new pyrimidine derivative is obtained and described, which effectively inhibits the growth of cancer cells with the expression of C797S-mutant EGFR and MET-amplification, which are the main mechanisms of resistance to third-generation anti-cancer drugs targeting EGFR, and thus can be effectively used for lung cancer treatment. n n n n Formula I n 7 cl, 2 tbl, 18 ex |
| priorityDate | 2017-12-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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