http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2742772-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bcb184ffd7230187a2e62202085b2cf8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2020-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9fe0384362214dd8ad486ceaba0bd41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb15d2d2b906b65a9da7bce5b5cb1800 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e5190418cfe31c218aa82604232d5f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3740d21290eda1d8bac9e95845bf044c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_02f0a5ab325fbd6e0d1cd0d7cc6f583f |
| publicationDate | 2021-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2742772-C1 |
| titleOfInvention | 16-azatricyclo[9.4.1.02.10]hexadeca-2,12,14-trienes, a method for production thereof and use thereof as antitumour agents |
| abstract | FIELD: chemistry.SUBSTANCE: invention relates to organic synthesis, specifically to 16-azatricyclo[9.4.1.02.10]hexadeca-2,12,14-trienam of formula (1). Said compounds are referred to a class of heterocyclic compounds and can be used as key precursors in synthesis of valuable biologically active compounds and modern medicinal anti-cancer preparations. Compounds of the invention are obtained by reacting N-substituted azepines of formula (a) (where R = Et, Ph) with 1,2-cyclononadiene (CND) in the presence of a catalyst Co(acac)2(dppe)/Zn/ZnI2in molar ratio of CND : azepine: Co(acac)2(dppe) : Zn : ZnI2= (1.3-2.0):1:(0.05-0.15):(0.15-0.45):(0.1-0.3), in ampoule at 20-80°C, in 1,2-dichloroethane for 20-48 hours.(1),(a).EFFECT: disclosed 16-azatricyclo[9.4.1.02.10]hexadeca-2,12,14-trienes of formula (1) as anti-tumor agents.3 cl, 2 tbl, 2 ex |
| priorityDate | 2020-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 48.