http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2742765-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_33c922e05f6133b7d72dbb849d77487d |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C237-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C271-22 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C237-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C231-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-06 |
| filingDate | 2018-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9990ded50895953cf8eff4d7ea9efa42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0a2780a02e87600eb4047b6848e9416 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_717e8fccee3f525ef0ff67c03ea453a2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a8120079a1b30927e8a726e268edf6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f61012842cd78dfaf115f77e2dd035d |
| publicationDate | 2021-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2742765-C1 |
| titleOfInvention | Method for preparing intermediate compound for synthesis of medicinal agent |
| abstract | FIELD: chemistry.SUBSTANCE: invention relates to a method of producing a compound of chemical formula 2, which is an intermediate compound used for synthesis of antidiabetic agents inhibiting the enzyme dipeptidyl peptidase IV. Method includes 1) a step of introducing a protective group P1into an amine group of a compound of chemical formula 6 to obtain a compound of chemical formula 5, in which the amine group is protected, 2) a step for producing a compound of chemical formula 4 by cyclisation through a condensation reaction of a compound of chemical formula 5 obtained in step 1), with paraformaldehyde and an acid catalyst, 3) a step for introducing a protective group P2into a carboxylic acid group of a compound of chemical formula 4 obtained in step 2), and converting a carboxylic acid group to an ester group to obtain a compound of chemical formula 3 and 4) a step for reacting ammonia as a nitrogen source with a compound of chemical formula 3 obtained at step 3), to obtain an amide compound of chemical formula 2 through decyclization of oxazolidinone. In compounds of chemical formulas 2−5 P1is Boc (butyloxycarbonyl), Cbz (benzyloxycarbonyl) or Fmoc (9-fluorenylmethyloxycarbonyl) as an amine protecting group, and P2is a protective carboxylic acid group.[Chemical formula 6][Chemical formula 5][Chemical formula 4][Chemical formula 3][Chemical formula 2]EFFECT: technical result is higher yield of compound of chemical formula 2.14 cl, 4 ex |
| priorityDate | 2017-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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