| abstract |
FIELD: pharmaceuticals.SUBSTANCE: invention relates to a method of treating cancer. Method of treating cancer involves administering to a subject a composition comprising apilimod or a pharmaceutically acceptable salt thereof, in an amount effective for inhibiting cellular PIKfyve activity in the individual's cancer cells, and administering an additional agent selected from signaling point control point inhibitors, including a trigger for programmed death of 1 (PD-1) and/or its ligands (PD-L1/2).EFFECT: invention provides treating cancer in a subject in need thereof by synergetic action occurring when using apilimod in combination with PD-1 or PD-L1/2 inhibitors.17 cl, 9 dwg, 10 tbl, 7 ex |