| abstract |
FIELD: chemistry. n SUBSTANCE: invention relates to a compound having a chemical structure: PTM-L-CLM, where L is covalently bonded to said PTM and said CLM and is presented in the form of formula -(A') q- , PTM is a low-molecular-weight protein-focused fragment, which specifically binds to an intracellular target protein or intracellular target polypeptide for performing ubiquitination of intracellular target protein or intracellular target polypeptide when coupled with CLM; CLM is a fragment which binds the ubiquitin-ligase E3, which has a chemical structure represented by the formula: n n n n n n n . n Values of other radicals are given in the patent claim. Invention also relates to pharmaceutical compositions, methods for inducing destruction of intracellular protein target or intracellular polypeptide target, compounds. n EFFECT: obtaining novel bifunctional compounds providing recruitment of proteins to ubiquitin-ligase E3 for their destruction. n 24 cl, 1 dwg, 1 tbl |