| abstract |
FIELD: biotechnology.SUBSTANCE: presented are immunogenic peptides used as a component of a vaccine composition against coronavirus infection COVID-19, having structures presented in Fig. 1. Described is a vaccine for coronavirus infection COVID-19, containing various combinations of said peptides: peptide immunogens having amino acid sequences SEQ ID NO: 1, SEQ ID NO: 3 and SEQ ID NO: 5; or peptide immunogens having amino acid sequences SEQ ID NO: 2, SEQ ID NO: 4 and SEQ ID NO: 6; or peptide immunogens having amino acid sequences SEQ ID NO: 4 and SEQ ID NO: 6; or peptide immunogens having amino acid sequences SEQ ID NO: 4 and SEQ ID NO: 7. Said peptide immunogens are covalently bound in the form of conjugates with a carrier protein, and the mixture of said conjugates of peptide immunogens and carrier protein is sorbed on a pharmaceutically acceptable adjuvant.EFFECT: technical result of the invention is obtaining such peptide immunogens and vaccine compositions, which carry minimally required antigenic determinants to form a specific immune response in rabbits, ferrets and hamsters and induce the protective immunity against COVID-19.9 cl, 5 dwg, 4 tbl, 7 ex |