| abstract |
FIELD: medicine. n SUBSTANCE: group of inventions can be used for preparing the high bioavailability of the oromucosal pharmaceutical compositions. Disclosed is a composite obtained by complexing API in hydroxypropyl-β-cyclodextrin, carried out in the presence of sucralose, where composite has molar ratio HPβCD: sucralose from 1:0.05 to 1:0.8 and API is a steroid, as well as a composite on an aqueous carrier. Also disclosed are a method of producing a composite and a pharmaceutical composition for the oromucosal administration containing it; using the composition or composite for treating a disease characterized by reduced production of a steroid. n EFFECT: group of inventions increases bioavailability of API due to selective mixing of sucralose with steroid active principles in combination with HPβCD. n 16 cl, 2 dwg, 8 tbl, 11 ex |