| abstract |
FIELD: chemistry.SUBSTANCE: invention relates to a compound of general formula II, in which ring A is selected from rings A-1, A-2 and A-3, having structures:, where wavy line, denoted 1, indicates point of connection of ring A to ring B, and corrugated line, denoted 2, indicates point of connection of ring A to W; X is N or CH; Y is H or F; R1is H; ring B is selected from rings B-1, having the structure:, where wavy line, denoted by 3, indicates point of connection to ring A, and corrugated line, denoted by 4, indicates point of attachment to pyrazolo[1,5-a]pyrimidine ring of formula II; W is O, NH or CH2, wherein when ring A is A-2, W is CH2; m is 0 or 1; D is carbon, R2and R2aare independently H or (1–3 C)alkyl, and R3and R3aare independently H or (1–3 C)alkyl, P1is H or a group protecting the carboxyl group; and R5and R6independently are H.EFFECT: obtaining novel compounds of general formula II, which are used as starting compounds for producing macrocyclic compounds which are Trk kinase inhibitors.13 cl, 1 tbl, 45 ex |