http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2734501-C2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c9a8c5fee3bdef921766ef882b27a740 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-473 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-147 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4355 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4355 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-147 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-473 |
| filingDate | 2017-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f4737fa91c7e61f09c3ec5a4fb4fdfc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92c88acfc16c1a5262e45bcfe8358454 |
| publicationDate | 2020-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2734501-C2 |
| titleOfInvention | Selective estrogen receptor inhibitors and use thereof |
| abstract | FIELD: pharmaceuticals.SUBSTANCE: invention refers to compounds of formulas (I) and (II) and their pharmaceutically acceptable salts possessing properties of selective estrogen receptor inhibitors. In formula (I) A is -CH= or -N= depending on valence; W is -NH- or -O-; a is equal to 1; n is 1, 2, 3 or 4; each Rindependently represents hydrogen, F, Cl, unsubstituted Calkyl, -CF, -ORor -CN; Rdenotes hydrogen, unsubstituted Calkyl or CF; Rdenotes hydrogen, halogen or unsubstituted Calkyl; Ris hydrogen, halogen or unsubstituted Calkyl; Rdenotes chlorine; Rdenotes fluorine or chlorine; Ris -CHF; Ris hydrogen or unsubstituted Calkyl. In formula (II) A is -CH= or -N= depending on valence; W is -NH-, -O- or -S-; a is equal to 1; each Rindependently represents hydrogen, F, Cl, -CF, unsubstituted Calkyl, -ORor -CN; Rdenotes hydrogen, unsubstituted Calkyl or -CF; Rdenotes hydrogen, F or unsubstituted Calkyl; Ris hydrogen, F or unsubstituted Calkyl, or Rand Rtaken together with intermediate atoms form unsubstituted cyclopropyl; Rrepresents hydrogen, halogen or methyl; Rrepresents unsubstituted Calkyl, chloro or fluoro; Ris unsubstituted Calkyl, chlorine or fluorine; wherein: (i) Ror Ris chlorine or (ii) both Rand Rare chlorine; Ris hydrogen or unsubstituted Calkyl. Invention also relates to pharmaceutical composition, containing an effective amount of compounds of formulas (I) or (II) or their pharmaceutically acceptable salts and a pharmaceutically acceptable excipient. Described also is a method of treating a proliferative disease associated with estrogen receptor activity, comprising administering to a subject in need of treatment, effective amount of the pharmaceutical composition of the invention.EFFECT: presented are selective estrogen receptor inhibitors and their application.18 cl, 3 dwg, 8 tbl, 14 ex |
| priorityDate | 2016-02-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 583.