| abstract |
FIELD: medicine; pharmaceuticals.SUBSTANCE: invention relates to a compound of formula (I-a), in which ring A is 5-member or 9-member heteroaryl containing 2–4 nitrogen atoms; where ring A is attached through a nitrogen atom; Rdenotes unsubstituted Calkyl or alkoxyCalkyl; Ris hydrogen; Ris hydrogen and Ris hydrogen; Ris hydrogen; Ris unsubstituted Calkyl, hydroxyCalkyl, haloCalkyl, halogen, cyano, nitro, OR, C(=O)OR, N(R)(R), C(=O)N(R)(R) or N(R)C(=O)R; n has value 1; Rrepresents hydrogen or unsubstituted Calkyl and each of Rand Rindependently represents hydrogen or unsubstituted Calkyl; Rdenotes hydrogen; each of Rand Rindependently represents hydrogen andrepresents a simple bond. Invention also relates to individual compounds, a pharmaceutical composition, a method of treating convulsions, a method of treating epilepsy, a method of treating a CNS-related disorder.(I-a).EFFECT: obtaining novel compounds of formula (I-a), having properties of GABA modulators.38 cl, 3 tbl, 161 ex |