http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2733697-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d584042a524740a406723fe1631e49e5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-48 |
| filingDate | 2020-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_00e88a27025afb09de3e499f3a759667 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8dd27a6681b47362f2a6b01227c96ee6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69ae6bf55645be11a74dc2b79b7ed89d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69ea63d0b9b4a7b9d60d84cb963974c8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79cb399c79fccaff1105b3a3002c464e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f6b4249a4deb81434adf0ec32d4e1f5 |
| publicationDate | 2020-10-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2733697-C1 |
| titleOfInvention | Method for prediction of risk of developing distant metastases in patients with operable forms of breast cancer with metastases in regional lymph nodes |
| abstract | FIELD: medicine.SUBSTANCE: present invention refers to medicine, namely to oncology, and concerns prediction of risk of developing distant metastases in patients with operable forms of breast cancer with metastases in regional lymph nodes. That is ensured by determining molecular-biological tumour parameters in breast tissue samples and evaluating the scores, considering the extent of regional lymph nodes (X1) involvement into the metastasis process, tumour proliferative activity marker value Ki67 (%) (X2); HER-2 receptor (X3) expression, oestrogen receptor (X4) expression, progesterone receptor (X5) expression, chymotrypsin-like activity of proteasomes in tumour tissue (CLA) (UE*10IU/mg protein) (X6); caspase-like activity of proteasomes (CALA) (UE*10IU/mg protein) and activity of calpaines (AC) (UE*10IU/mg protein) in tumour and intact tissue, coefficient of caspase-like activity of proteasomes (cCLA) (X7), and an coefficient of activity of calpaines (cAC) (X8). Values of logistic regression equation Y: Y = −140.77 + 253.314*X1 − 4.851*X2 + 375.064*X3 − 378.390*X4 + 2.537*X5 + 2.399*X6 + 49.752*X7+3.530*X8, (1) probability of developing hematogenic metastases P is determined by formula (2): P = 1/(1+e), (2) where e is a mathematical constant equal to 2.72. When P ≥ 50 % is high, and if P <50 %, low risk of developing distant metastases.EFFECT: method provides high accuracy of diagnosis by taking into account pathogenetic involvement of said pathogenetic factors.1 cl, 2 ex |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2796769-C1 |
| priorityDate | 2020-03-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 219.