| abstract |
FIELD: medicine.SUBSTANCE: present invention relates to a derivative applicable in medicine, a composition based thereon and preparation thereof. Disclosed is a derivative of formula 1 or 2, their stereoisomerwhere Ar is phenyl; Rand Rare selected from H, F, Cl, CH, OH; Rrepresents H or CH; X is oxygen or ethanediyl-1,1(C=CH); Y is CH(R)(CH), CH(R)(CH)C(O)O(CH); Rdenotes H or CH; k has value from zero to six; m has a value from zero to two; n has value from one to four; Q is a radical selected from Q1–Q4;where Ris a substitute selected from H, F, Cl, CH, OH; arrow (→) indicates connection point Q1–Q4. Disclosed process for producing compounds according to claim 1 or 2 includes cyclisation of acid of formula 3 or 16where Ar, R, R, R, X, Y and Q are defined above. What is presented is a novel effective derivative for treating hepatitis C and an effective process for preparing it, as well as a pharmaceutical composition based thereon.EFFECT: disclosed derivative is a pro-drug for treating viral diseases and is an inhibitor of HCV NS5B polymerase, HBV DNA polymerase and HIV-1 reverse transcriptase.10 cl, 19 ex |