http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2730604-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_52490458f9d42fb58ffd4beb4bbbc310 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0055 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate | 2019-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1be38bc32d58958e1fd4b5e0100c3173 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4adb5e3e8ede7d18870add884285b1d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8b2e46f0476188f952a7172747f9d83c |
| publicationDate | 2020-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2730604-C1 |
| titleOfInvention | (2z)-2-[(3β, 4α, 8α, 11α, 14β, 16β)-16-(acetyloxy)-3-({3-[(4-aminobutyl)amino]propyl}amino)-11-hydroxy-4,8,10,14-tetramethyl gonane-17-ylidene]-6-methylhept-5-enoic acid with antimicrobial and fungicidal activity and method for production thereof |
| abstract | FIELD: chemistry.SUBSTANCE: invention relates to synthesis of biologically active analogues of natural compounds, specifically to production of a new representative of nitrogen-containing derivatives of fusidic acid - (2Z)-2-[(3β,4α,8α,11α,14β,16β)-16-(acetyloxy)-3-({3-[(4-aminobutyl)amino]propyl}amino)-11-hydroxy-4,8,10,14-tetramethyl-gonan-17-ylidene]-6-methylhept-5-enoic acid (compound (1)), having antibacterial activity on Staphylococcus aureus (MRSA) and inhibiting growth of a fungal culture of Cryptococcus neoformans. Compound (1) is obtained based on the corresponding dioxo-derivative of fusidic acid by reacting with 6 equivalents of spermidine in the presence of titanium (IV) isopropoxide in dry methanol medium while stirring for 2 hours. Output of compound (1) is 90 %.EFFECT: compound (1) shows fungicidal activity with respect to the pathogenic fungal culture of Cryptococcus neoformans with low toxicity and has minimal haemolytic action at the maximum tested concentration.2 cl, 2 tbl, 1 ex |
| priorityDate | 2019-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.