http://rdf.ncbi.nlm.nih.gov/pubchem/patent/RU-2730492-C1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e5421b664c7c22ec24417a9e81faa650 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-61 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-02 |
| filingDate | 2019-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5798fbd6474c23f46f60aea2d400335 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4359117c519194abd812f61bb10d67cb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2ed59319f7d7330c6c4a01995d281cdf |
| publicationDate | 2020-08-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | RU-2730492-C1 |
| titleOfInvention | Method of producing alkyl 2-[([1,1'-biphenyl]-4-carbonyl)amino]-3-(1h-azol-1-yl) propanoates |
| abstract | FIELD: chemistry. n SUBSTANCE: invention relates to organic chemistry and specifically to a method of producing alkyl 2-[([1,1'-biphenyl]-4-carbonyl)amino]-3-(1H-azol-1-yl) propanoates of general formula I n , n where R denotes an imidazole or triazole heterocyclic moiety, R1 denotes alkyl groups of a straight or branched structure with 1 to 4 carbon atoms. Method, which comprises condensing carboxylic acid 4-biphenyl acid chloride with L-serine alkyl ester hydrochloride in aprotic polar solvent, acetonitrile in presence of triethylamine to obtain alkyl 2-[([1,1'-biphenyl]-4-carbonyl)amino]-3-hydroxypropanoate, the obtained amide is converted into an oxazoline derivative in an aprotic nonpolar solvent in presence of 20-21-fold molar excess of thionyl chloride at 0–5 °C. Further, alkyl 2-([1,1'-biphenyl]-4-yl)-4,5-dihydro-1,3-oxazole-4-carboxylate is disclosed by imidazole or triazole in presence of 1–1.001 mol% of zinc chloride at temperature of 145–150 °C without a solvent in melt for 20–30 hours to obtain the desired compound of formula I. n EFFECT: technical result: novel method of producing alkyl 2-[([1,1'-biphenyl]-4-carbonyl)amino]-3-(1H-azol-1-yl) propanoate, having a higher yield of the product and being a cheaper method. n 1 cl, 3 tbl, 10 ex |
| priorityDate | 2019-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 281.