| abstract |
FIELD: organic chemistry. n SUBSTANCE: invention relates to a compound of formula (I) n n n n or a pharmaceutically acceptable salt thereof, wherein R 1 is cyclopropyl, C 1 -C 4 -alkyl or haloazetidinyl; R 2 is cyclopropylmethoxy, C 1 -C 4 -alkoxy, haloC 1 -C 4 -alkoxy, halopyridinyl, alkylpyrazolyl or halopyrrolidinyl; provided that at least one of R 1 and R 2 is cyclopropyl or cyclopropylmethoxy; R 3 is -C(O)-NH-C(R 4 R 5 )-R 6 , -C(O)-R 7 or R 8 ; R 4 and R 5 are independently selected from hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -cycloalkyl, C 1 -C 4 -cycloalkyl C 1 -C 4 -alkyl, C 1 -C 4 -alkylsulfonylC 1 -C 4 -alkyl and C 1 -C 4 -alkyloxetanil; or R 4 and R 5 together with the carbon atom to which they are bonded, form oxetanyl or dioxothetanyl; R 6 represents aminocarbonyl, 5-methyl-1,2,4-oxadiazol-3-yl, hydroxyC 1 -C 4 -alkyl, thiazolyl, C 1 -C 4 -alkoxycarbonyl, carboxy, difluoroazetidinylcarbonyl, 5-amino-1, 2,4-oxadiazol-3-yl, C 1 -C 4 -alkylaminocarbonyl or aminocarbonyl C 1 -C 4 -alkyl; R 7 is (aminocarbonyl)(difluoro)pyrrolidinyl or (aminocarbonyl)azaspiro[2.4]heptyl; R 8 is 3-C 1 -C 4 -alkyl-1,2,4-oxadiazol-5-yl or 5-C 1 -C 4 -alkyl-1,2,4-oxadiazol-3-yl. Invention also relates to a pharmaceutical composition, use and to a method for activating cannabinoid receptors 2. n EFFECT: obtaining novel organic compounds which are selective agonists of cannabinoid receptors 2. n 17 cl, 74 ex |