| abstract |
FIELD: pharmaceuticals. n SUBSTANCE: invention relates to a compound of formula I or a pharmaceutically acceptable salt thereof, wherein Z is halo-substituted phenoxymethylcarbonyl; A is -CH 2 -; B and D are hydrogen; R 1 denotes hydrogen; R 2 is hydrogen and R 3 is selected from a group consisting of cyclohexyl, cyclopentyl, morpholino, phenyl, piperidinyl, pyridinyl, tetrahydrofuranyl, tetrahydropyranyl, 1,2,3,4-tetrahydronaphthyl and thiazolyl, each of which is independently unsubstituted or independently substituted with 1–3 members selected from methyl, methoxy, trifluoromethyl, acetyl and -N 3 ; and R 4 is hydrogen. n . n EFFECT: compounds of formula I are intended for inhibiting lysine-specific gingipain Porphyromonas gingivalis . n 8 cl, 10 dwg, 2 tbl, 37 ex |