| abstract |
FIELD: medicine; pharmaceuticals.SUBSTANCE: invention relates to derivatives of general formula (II),where Y and Z are -O- and A is,where R1, R2, R3 independently represent OCH; X is O; n equals 3 and m equals 1.EFFECT: obtaining novel derivatives with bortezomib via boronic diester bonds, which are stable in a neutral medium, but which are capable of splitting in a slightly acidic medium (pH = 4_5–5_0), selecting a bortezomib for drug delivery, which can be used for transfer and extraction of bortezomib.9 cl, 5 tbl, 14 dwg |